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Aktivace mitochondriální glycerol-3-fosfátdehydrogenázy různými analogy koenzymu Q
Rauchová, Hana ; Mikšík, Ivan ; Fato, R. ; Bergamini, C. ; Lenaz, G.
The aim of our study was to test the synthetic analogues of coenzyme Q (CoQ) on the activity of mitochondrial glycerol-3-phosphate dehydrogenase. We used idebenone and its two derivatives: methoxyidebenone and acetylidebenone and three other componds in which aliphatic chain of CoQ was substituted by thiazoimidazol type groups. The present results can support our previous data suggesting differences between mitochondrial glycerol-3-phosphate dehydrogenase and other dehydrogenases of respiratory chain in the transfer of reducing equivalents to the CoQ pool
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Charakterizace klonů odvozených od kolorektální nádorově buněčné linie HT29
Šloncová, Eva ; Kučerová, Dana ; Vojtěchová, Martina ; Turečková, Jolana ; Tuháčková, Zdena ; Sovová, Vlasta
During our analysis of HT29 cell line we established several clones, which differed in the expression of some molecular markers, e.g. phosphorylation of Src protein, PKCbeta2 activity, CEA-CAM1 expression and in the response to the differentiating effect of sodium butyrate, indicated by activity of alkaline phosphatase
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